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Study Identifies Cytokine Target for Treatment-Resistant Hemophilia A – MD Magazine

Elevated B cell activating factor levels in children and adults were associated with the development of FVIII inhibitors, which may lead to FVIII infusion failures….



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Findings from a new study shed light on the mechanisms behind patient unresponsiveness to coagulation protein therapy for hemophilia A.
More specifically, investigators note a key target that may lead to treatment failure in up to 30% of patients.
Currently, hemophilia is the most common inherited bleeding disorder, which affects 1 in 10,000 men across the globe. Since patients lack coagulation factor VIII (FVIII), therapies are typically aimed at infusions to replace the missing protein.
Some patients,…

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